The Dutchman's side lost 2-1 to the Magpies at Wembley Stadium on Sunday (16.03.25) and the manager believes the game played out in a way that benefitted Eddie Howe's men's style.
Speaking in the post-match press conference, he said: "If you look at the result and the performance you might feel that it maybe did something to us, but I prefer to look at how the game went and this game went exactly the way they wanted it to be - a fight with a lot of duels and a lot of duels through the air.
"If we played a game of football through the air against them 10 times, they win it probably nine times because they are a stronger team through the air than us, which led to the first goal and the second goal. They are stronger in that part of football than us and that's why they beat us."
And when it was suggested Newcastle outplayed Liverpool, he added: "They won more duels than us. Is that outworking? Or is that one of their biggest qualities, to play so many aerial duels and to win these physical duels?
"Outplayed for me is if you don't touch the ball and they play through you every single time you try to press them, and every time you're too late. But I agree if you say that they deserved to win because the game went in the way they wanted it to go.
"So yes, they deserve to win. But it wasn't like we were only running after them. We had to defend a lot of long balls, second balls and that's their strength."
The defeat occurred just days after Liverpool crashed out of the Champions League after losing to Paris St. Germain, and while Slot noted it had been a "tough week", he doesn't think it was completely unexpected.
He said: "It was a tough week, but it was also a week where we extended our lead to 12 points, so it wasn't all negative, but the last two [games] were definitely not the way we wanted it to be.
"But it's not for the first time in their [Liverpool's] history - or in the last two seasons - they've lost two games in a row. This is part of playing football.
"If you go far in tournaments that the opposition in your face gets stronger and stronger and then even Liverpool can lose football games. That's what can happen."