The Chinese tech company has unveiled its Mate 70 range, which starts at 5,499 yuan (£603), and runs on HarmonyOS.
The move away from Android is to give customers more of a choice when buying a device powered by the green robot software, or Apple's IOS.
As the tech firm has been the subject of U.S export restrictions since 2019, it will also allow the company to dodge more sanctions, such as Google not being allowed to give Huawei devices its latest Android operating system.
Richard Yu, Chairman of Huawei's consumer business, said at Tuesday's (26.11.24) launch: "This is our most powerful phone (in the Mate series).
"We have always been copied but never surpassed."
He added that all of Huawei's devices will be using the new software from next year.
The Mate 70 is the successor to the Mate 60, which has become a symbol of the technology rivalry between the U.S and China.
Lucas Zhong, Canalys Research Analyst, told CNN: "[The shift] will be essential for Huawei to maintain momentum in the premium segment, solidify consumer loyalty, and attract potential platform switchers."